Year-end Sale % OFF 
Abstract
Background:Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer’s disease in Gorgan and compare it with a healthy control group.Method:The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of PON1 were determined.Result:There were significant differences in distribution of genotypes and alleles among patients and control group. The most common genotype was CT in patients and control group, while the most frequent alleles were T and C in patients and controls, respectively. There was a statistically significant variation between serum PON1 activity and –108C> T polymorphism. The highest PON1 enzyme activities in the patients and controls were found in CC, while lower enzyme activities were seen in CT and TT genotypes in both genders and age groups.Conclusion:Onset of Alzheimer’s disease may depend on different polymorphisms of the PON1 enzyme. Late or early-onset of Alzheimer’s disease may also depend on age and gender distribution, especially for arylesterase enzyme. Further studies on polymorphism of the enzyme are necessary for interpretation of possible polymorphic effects of enzyme on PON1 activity in humans.
Highlights
Alzheimer’s disease (AD) is the most common type of dementia [1]
Secreted paraoxonase 1 (PON1) and PON3 enzymes from liver cells are found in the blood circulation bound to high-density lipoproteins, while PON1 activity predominates in human serum [29]
This study revealed the PON1 activity and the genotype and allele frequencies for 108C>T polymorphism of this gene in Alzheimer’s patients and healthy controls
Summary
Alzheimer’s disease (AD) is the most common type of dementia [1]. It affects one in eight individuals aged over 60 years [2]. Human PON1 exhibits both paraoxonase and arylesterase activities. PON1 is associated with high-density lipoprotein (HDL) [11]. The expression of PON gene family members occurs in different types of tissues in the human body [27]. Secreted PON1 and PON3 enzymes from liver cells are found in the blood circulation bound to high-density lipoproteins, while PON1 activity predominates in human serum [29]. Several polymorphisms of PON1 gene have been reported These polymorphisms may be associated with PON1 expression and enzyme activity [31 - 38]. Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer’s disease in Gorgan and compare it with a healthy control group
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
