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Abstract
Anti-glomerular basement membrane (anti-GBM) disease represents the spectrum of disease attributable to circulating anti-GBM antibodies. While active anti-GBM disease in the absence of circulating anti-GBM antibodies has been described, it...
Highlights
Anti-glomerular basement membrane disease represents the spectrum of disease attributable to circulating anti-GBM antibodies
We describe four subjects with active alveolar haemorrhage due to anti-GBM disease despite negative anti-GBM antibodies by routinely available contemporary techniques
The formation and deposition of anti-GBM antibodies along the glomerular and alveolar basement membranes is the pathological hallmark of anti-GBM disease,[1] and there is compelling evidence that these antibodies are directly pathogenic.[8 9]
Summary
Anti-glomerular basement membrane (anti-GBM) disease represents the spectrum of disease attributable to circulating anti-GBM antibodies. +, positive; 2, negative; ND, not performed; Prot, protein; ELISA, enzyme linked immunosorbent assay; KCO, carbon monoxide transfer factor; GBM, glomerular basement membrane; ANCA, anti-neutrophil cytoplasmic antibodies; IIF, indirect immunofluorescence; MPO, myeloperoxidase; PR3, proteinase-3; Unint, uninterpretable.
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