Alternative Synthesis of 5-Chloromethyl-2,3-Dimethoxy-6-Methyl-1,4-Benzoquinone: A Key Intermediate for Preparing Coenzyme Q Analogues

Abstract

The title compound, a key intermediate for preparing Coenzyme Qn family, was prepared in high yield by a reaction sequence starting from the commercially available 3, 4, 5-trimethoxy-benzadehyde via Wolff–Kishner reduction, Vilsmeier–Haack reaction, Blanc chloromethylation reaction, Dakin reaction and oxidation.