Abstract
Objectives The study was intended to access metabolic syndrome in hypothyroid patients and to investigate the association between hypothyroidism and metabolism syndrome inMeerut district.Methods The study was done on patients with symptoms of hypothyroidism or follow up cases of hypothyroidism having metabolic syndrome. T3, T4 and TSH were analysed by enzyme linked fluorescent assay (ELFA) technique using Minividas auto analyser fromBiomeriuex,France. Fasting blood sugar and lipid profile were estimated by Vitros-250 auto analyser using readymade dry chemistry kits from Ortho-Clinical diagnostics,Johnson&Johnson,USA. The data was analysed using SPSS-16 software package.Result In overt hypothyroid cases T3 values were found to be negatively correlated with waist circumference (WC), diastolic BP, FBS and TG level and positively correlated with FBS (p=0.03, r=0.24) in subclinical hypothyroidism.T4 values negatively correlated with FBS and TG level in overt hypothyroid group and with WC, systolic and diastolic BP in subclinical group. But there was significant positive correlation with TG levels (p=0.04, r = 0.23).TSH values shows negative correlation with WC, FBS, TG and HDL levels in overt hypothyroidism.Conclusion This study on metabolic syndrome in thyroid dysfunction population may help us to plan management strategies, resulting in significant reduction in cardiovascular morbidity and mortality due to metabolic syndrome.
Highlights
Thyroid hormones play an important role in regulating energy homeostasis, glucose and lipid metabolism[1]
According to most recent definitions proposed by the International Diabetes Federation (IDF) 2005, a person is identified as having the metabolic syndrome if they have central obesity plus any two of the following: raised TG; reduced high density lipid cholesterol (HDL-C); raised blood pressure (BP); or raised fasting blood glucose[8]
The percentage of metabolic syndrome is increasing with age with maximum (70 %) in age group 60-69 years and we have observed that maximum percentage of overt and subclinical hypothyroid patients were in age group of 30-39 years with 57.14 % (n=24) of metabolic syndrome.(Table 1)
Summary
Thyroid hormones play an important role in regulating energy homeostasis, glucose and lipid metabolism[1]. Thyroid function affect metabolic syndrome (Met Syn) parameters including high density lipid cholesterol (HDL-C), triglycerides (TG), blood pressure (BP) and fasting blood glucose (FBS). It is known that overt hypothyroidism lead to an increase in plasma cholesterol levels and blood pressure. Met Syn is a cluster of physical condition and metabolic abnormalities commonly found in association with increased risk for development of Type 2 Diabetes Mellitus (Type 2 DM), cardiovascular disease and other medical conditions[4,5,6,7]. According to most recent definitions proposed by the International Diabetes Federation (IDF) 2005, a person is identified as having the metabolic syndrome if they have central obesity (defined as waist circumference with ethnicity specific values) plus any two of the following: raised TG; reduced HDL-C; raised BP; or raised fasting blood glucose[8]. This study was intended to access metabolic syndrome in hypothyroidism patients and to investigate the association between hypothyroidism and metabolism syndrome in Meerut district
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