Abstract
Duchenne muscular dystrophy is a lethal muscle wasting disease caused by the absence of dystrophin, a protein that directly links the cytoskeleton to the extracellular matrix through the dystrophin-glycoprotein complex. Cells generate, sense and respond to forces via mechanosensitive protein complexes, and altered force transmission via these complexes such as focal adhesions (FAs) are known to contribute to muscular dystrophy development and progression. However, the interplay between dystrophin loss and FAs force transmission remains unknown.
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