Abstract
BackgroundDifferent lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients.MethodsSeventy T2DM patients were studied and 34 showed altered SWM results. The clinical and biochemical parameters were determined using standardized methods. Levels of oxidized glutathione (GSSG) and malondialdehyde (MDA) were measured in circulating mononuclear cells using high-performance liquid chromatography.ResultsWe found that T2DM patients with altered SWM test results had significantly higher GSSG (3.53 ± 0.31 vs. 3.31 ± 0.35 mmol/ml, p < 0.05) and MDA (1.88 ± 0.16 vs. 1.75 ± 0.19 nmol/ml, p < 0.01) values compared to diabetic patients with normal SWM test outcomes. Moreover, altered SWM test results were independently related to age, glycosylated hemoglobin, and GSSG levels, but there was no association between OS markers and altered neuropathy sensitivity score (NSS) values.ConclusionsAlteration of the glutathione system and MDA values in T2DM patients are associated with loss of proprioceptive (pressure) sensitivity, but not with symptomatic polyneuropathy (as evaluated by NSS). This finding may be important for understanding how OS affects distal symmetric polyneuropathy in diabetic patients.
Highlights
Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy
Comparing the studied parameters between type 2 diabetes mellitus (T2DM) groups (Table 1), we observed no significant differences in age, gender distribution, disease duration, body mass index (BMI), waist circumference, smoking habits, glycosylated hemoglobin (HbA1c), or renal function between the groups
We found significant differences in the prevalence of diabetic retinopathy in T2DM patients with altered Semmes–Weinstein monofilament (SWM) test results compared to those with normal SWM test outcomes (39% vs. 13%), and this latter group showed significantly higher consumption of oral hypoglycemic agents than the former group
Summary
Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. We analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients. The SWM test can be used to diagnose the absence of proprioceptive sensitivity (i.e. individuals’ ability to detect pressure) and to indicate the presence of distal nerve lesions in type 2 diabetes (T2DM) patients. Foot ulceration is a complication of DSPN and is a significant cause of morbidity and mortality in diabetic patients [2]. Several lines of evidence suggest that oxidative stress (OS) is Martinez‐Hervás et al J Transl Med (2017) 15:187 implicated in the pathogenesis of diabetic neuropathy [3, 4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
