Abstract
Background: Objective markers for the severity of motor dysfunction are warranted for clinical trials in patients with Huntington's Disease (HD). Specific impairments in the control of isometric grip forces were found in grasping, holding, and transport tasks in HD. In previous studies we identified „grip force variability“ (GFV) as a measure correlated (1) to the clinical severity of the disease as assessed in the UHDRS, (2) to the amount of neurodegeneration in MRI volumetry, and (3) to the CAG repeat length when corrected for the age of patients. Thus GFV may be a surrogate marker to objectively assess the severity of HD. While the initiation and maintenance of grip forces in grasping and lifting has intensively been investigated in HD, it is unknown if specific impairments occur during object release in HD.
Published Version
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