Altered Functional Brain Dynamics in Chromosome 22q11.2 Deletion Syndrome During Facial Affect Processing

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Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multisystem disorder associated with multiple congenital anomalies, variable medical features, and neurodevelopmental differences resulting in diverse psychiatric phenotypes, including psychosis, facial memory and social cognitive deficits. Neuroimaging in individuals with 22q11.2DS has revealed differences in BOLD fMRI activation relative to matched controls in BOLD fMRI activation during facial affect processing tasks, but time-varying functional interactions between brain areas have not yet been compared in this context.