Abstract
The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.
Highlights
The basal ganglia primarily consist of four nuclei: the striatum, the globus pallidus, the subthalamic nucleus, and the substantia nigra (Parent, 1990; Luo et al, 2012)
Many symptoms in basal ganglia-related disorders (e.g., Huntington’s disease and Parkinson’s disease), such as cognitive defects, involuntary movements, affective disturbances, and catatonia, are phenotypically similar to the symptoms observed in schizophrenia patients (Zampieri et al, 2014)
The current study aimed to investigate whether and how spontaneous neuronal activity in the basal ganglia is changed in schizophrenia patients
Summary
The basal ganglia primarily consist of four nuclei: the striatum, the globus pallidus, the subthalamic nucleus, and the substantia nigra (Parent, 1990; Luo et al, 2012). The basal ganglia receive afferent inputs from the different cortex areas and send projections back to the cortex via the thalamus. Many symptoms in basal ganglia-related disorders (e.g., Huntington’s disease and Parkinson’s disease), such as cognitive defects, involuntary movements, affective disturbances, and catatonia, are phenotypically similar to the symptoms observed in schizophrenia patients (Zampieri et al, 2014). This phenomenon implies the possibility of basal ganglia pathology in schizophrenia
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