Abstract
Pharmaco kinetics is a critical branch of pharmacology, emphasizes on how the body operates drugs, along with their absorption, distribution, metabolism and excretion. In all patients, the absorption of orally administered drugs can be influenced by gastro intestinal disturbances, altered pH levels and decreased blood flow to the intestine. In a very few illness, modifications in blood flow, protein levels and tissue binding can changes the distribution of drugs throughout the body. The liver acts as an important organ for metabolizing drugs and when it is compromised due to illness, drug metabolism can slow down or became erratic. Whatever it may be, in ill patients, renal function can be compromised leading to the occurrence of impaired drug excretion. Ill patients often gain multiple interactions to manage their conditions, enhancing the risk of drug drug interactions. Gastro intestinal motility, gastric pH, gastric blood flow and gasro intestinal surface area can influence drug absorption in an ill person. Finally it is concluded that understanding pharmaco kinetics in ill patients is a fundamental aspect of providing safe and effective medical care.
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