Abstract
Blood nitrite and nitrate of mice were determined using naphthylethylenediamine and a Cu-Cd reduction column. When mice were exposed to 40 ppm nitrogen dioxide, nitrite became constant in 10 min. Nitrite declined rapidly, with a half-life of several minutes, when mice were removed to room air. Nitrate showed changes similar to those of nitrite; however, the concentration in the blood was higher and the half-life was longer. Dose-effect relationships were also determined at concentrations ranging between 5 and 40 ppm for 1 hr exposure. No increase of methemoglobin was observed at these concentrations. Addition of fresh mouse blood to sodium nitrite in vitro indicated a rapid conversion of nitrite to nitrate with an increase of methemoglobin, whereas addition to sodium nitrate did not cause any changes. The fate of inhaled nitrogen dioxide in the living body is discussed based on the results obtained.
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