Abstract
The impact of acute infection on thyroid physiology was investigated in rats infected with a type-specific pneumococcus. Infected rats showed a lower thyroidal131I uptake than healthy controls at all time periods studied. Unlike in the rat, thyroidal131I uptake curves in the infected and healthy mouse and guinea pig were superimposable. Thyroidal131I release in the infected rat was significantly delayed when compared to similar release curves in uninfected animals. Although the thyroid of the infected rat responded to a physiologic dose of exogenous TSH, both its uptake and release of131I showed an absolute reduction. Serum TSH levels measured by bio-assay were not altered during infection. The disappearance time of131I-T4 from blood of infected rats was significantly shorter than that of healthy controls, while disappearance times of blood131I-T3 were unchanged. Organ radioactivity was measured following serial sacrifice after the administration of131I-T4 or 131I-T3 to healthy and infected rats. In the T...
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call