Alterations in plasma lipid profile patterns in leukoplakia and oral submucous fibrosis-a pilot study

Abstract

Introduction: Oral submucous fibrosis and leukoplakia are highly prevalent in India Lipids are the chief cell membrane components which are essential for various biological functions like cell growth and division of normal as well as malignant tissues. Lipids can be helpful for studying the variation in the cholesterol levels for diagnosing and treating the diseases. Aim: The present study evaluated the plasma lipid profiles in patients with Oral submucous fibrosis and leukoplakia and controls. Methodology: 21 patients were selected for the study out of which 7 had OSMF 7 had oral leukoplakia and 7 were included in control group. Patients with cardiovascular diseases, uncontrolled diabetes, acute hepatitis, thyroid dysfunction, and any drug history were excluded from the study. 5ml blood sample was taken and the serum was tested for triglycride levels(TG), total cholesterol (TC), LDL, HDL, LDL VLDL level were analyzed using triglycerides were analyzed by auto-analyzer used for the analysis of the results is a fully automated biochemistry analyzer. Results: In this study TC, HDL, LDL level analysis showed lower levels in oral leukoplakia and OSMF patients than that of the controls. Conclusion: The alterations in the plasma lipid profile patterns were considerable and recommend a still in-depth study with larger sample size in this aspect for early diagnosis and management of oral leukoplakia to prevent malignant transformation. Keywords: Lipids, Cholesterol, Triglycerides, Leukoplakia, Oral submucous fibrosis