Abstract
Objective: To evaluate and compare lipid profile level in oral submucous fibrosis (OSMF), oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) patients . Material and Methods: Thirty histopathologically diagnosed subjects each of OL, OSMF, OSCC were recruited along with 30 healthy controls. 5ml of venous blood is collected and estimated using standard diagnostic kits. Results: The mean of Total cholesterol level in controls was 219.03 mg%, in OSCC, OL and OSMF was 142.89 ± 10.21mg%, 155.44 ± 17.63 mg% and 180.60 ± 13.25 mg%, respectively. The mean low-density lipid level in controls was 137.24 mg and in OSCC, OL and OSMF groups were 109.28 ± 2.16 mg%, 126.63 ± 0.85 mg% and 119.15 ± 0.93 mg%, respectively. The mean of high-density lipid level in controls, OSCC, OL and OSMF was 42.87 ± 0.42 mg%, 36.50 ± 2.31 mg%, 21.13 ± 0.77 mg% and 28.37 ± 1.11mg%, respectively. The mean of very low density lipids level in controls, OSCC, OL and OSMF was 30.12 ± 1.51 mg%, 17.24 ± 0.80 mg%, 22.25 ± 0.93 mg% and 25.89 ± 0.43 mg%, respectively. The mean triglyceride level in controls, OSCC, OL and OSMF was 118.80 ± 9.47 mg%, 91.2 ± 3.03 mg%, 105.05 ± 2.96 mg% and 106.19 ± 3.09 mg%, respectively . Conclusion: Lipid profile levels could be early indicators of precancer and cancer.
Highlights
Cancer is one of the leading causes of adult death worldwide
The most widespread is the chewing of betel-quid with tobacco and this has been demonstrated as a major risk factor for cancers of the oral cavity
We evaluated the different biochemical lipid parameters such as total cholesterol (TC), triglyceride (TGL), high-density lipid (HDL), low-density lipid (LDL), very low-density lipid (VLDL) lipoprotein levels in oral submucous fibrosis (OSMF), oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC)
Summary
Cancer is one of the leading causes of adult death worldwide. Oral cancer is a serious problem in many countries [1]. Oral cancer is regarded as the ninth most common cause of malignancy worldwide and the third major cause of mortality in developing countries [2]. In India, oral cancer incidence is about 3 to 7 times more common compared to developed countries [3]. A high incidence of oral cancer (OC) is due to intense use of tobacco products. Cancer of the oral cavity is one of five leading sites of cancer in either sex [1]. The most widespread is the chewing of betel-quid with tobacco and this has been demonstrated as a major risk factor for cancers of the oral cavity
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