Abstract
The effects of aging and estradiol on the three major hypothalamic monoaminergic systems were measured in female C57BL/6J mice. Both aging and estradiol treatment induced small (10–15%) changes in the levels and ratios of the monoamines and their catabolites. In addition, the levels of 5-hydroxyindoleacetic acid, the major serotonergic catabolite, were strongly correlated with the levels of the two major dopaminergic catabolites, 3,4-dihydrophenylacetic acid and homovanillic acid. Aging affected the relattionship between 5-hydroxyindoleacetic acid and the dopaminergic catabolites such that the slope of the regression lines of 5-hydroxyindoleacetic acid on the dopaminergic compounds was increased in order mice. The age-related alteration in the correlations between the serotonergic and dopaminergic compounds may be due to an effect of aging on the acid export system.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call