Abstract
Total serum alkaline phosphatase (TSAP) determinations were done as part of the biochemical screening in comparative studies of lipid lowering agents in type lla hyperlipoproteinemic patients. TSAP determinations were made by using a modification of the Bessey-Lowry method and the Statland method. Increases in TSAP following colestipol treatment of 20% ( P < 0.05) and 32% ( P < 0.005) were seen by using the respective methods. Isoenzymatic determinations were done by employing the Statland method and all fractions were increased from baseline levels during colestipol therapy. Clofibrate was associated with 34% ( P < 0.005) and 28% ( P < 0.005) reductions in TSAP activity by using the respective methods; significant reductions in both “bone” and “other” isoenzymatic components occurred. Gamma-glutamyltransferase (γGT) results did not consistently reflect TSAP or “liver” isoenzyme results.
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