Abstract
In a kwashiorkor-like experimental model in which young rats were force-fed a purified diet devoid of threonine, the livers have previously been reported to show enhanced RNA and protein synthesis as well as a shift toward heavier polyribosomes with decreased monosomes in comparison with control animals force-fed the complete diet. As a follow-up study, this investigation reports chemical and electron microscopic evidence that there is an increase in hepatic ribosomes in rats fed the experimental diet and that this increase is relatively greater in the free ribosomal fraction than in the total or bound ribosomal fraction. The chemical evidence is based on analyses of hepatic free ribosomes, as well as by fractionation of liver homogenate into nuclear, ribosomal and soluble RNA fractions.
Published Version
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