Alterations in Biochemical Markers of Liver and Kidney Function and Oxidative Stress Indices on Sub-acute Exposure of Meloxicam in Albino Rats

Abstract

Background: The study was performed to study the alterations in biochemical markers of liver and kidney function and oxidative stress indices on sub-acute exposure of meloxicam in albino rats. Methods: The study was performed in three groups of rats, consisting six rats in each group. The rats of group I were served as control. However, rats of group II, III were treated with meloxicam @ 0.2 mg/kg b.wt. meloxicam @ 0.6 mg/kg b.wt. respectively. Result: Meloxicam administration induced oxidative stress in rats as indicated by significant decrease in concentration of catalase, superoxide dismutase and reduced glutathione in blood as compared to control. However, lipid peroxidation was significantly enhanced as indicated by increased level of MDA in blood as compared to control. Meloxicam altered the functions of liver and kidney as indicated by the alteration in the biochemical markers of liver and kidney function. Meloxicam significantly enhanced the concentration of biochemical markers of liver function viz. ALT, AST, GGT, ALP, albumin and bilirubin as compared to control. The concentration of biochemical markers of kidney function viz. BUN and creatinine was significantly enhanced after meloxicam administration as compared to control.