Alteration of Dna Structure: The Common Result of the Interaction Between DNA and Physical and Chemical Agents

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It is becoming evident that the majority, if not all, of mutagens and carcinogens bind, either covalently or not, to nucleic acids or induce chemical modifications in these target molecules. This interaction seems critical in both mutagenic and carcinogenic processes. Since the alterations in nucleic acid structure are likely to have functional consequences, it is important to gain a better understanding of the modifications in the target structure.