Abstract
Summary The tumor promoter phorbol 12-myristate 13-acetate alters the levels of both cGMP and cAMP in chick myoblasts. There is a transient 7-fold increase in cellular cGMP 40–60 sec after promoter addition. The changes in cAMP are slower with a 50% decrease at 30 min followed by a 3.5-fold increase at 3 h. The relationship between these cyclic nucleotide changes and the previously reported stimulation of hexose transport by the promoter [Fed. Proc. 37, 1817 (1978)] was investigated. Addition of 8-bromo cGMP, 8-bromo cAMP or phosphodiesterase inhibitors had no effect on hexose transport while LiCl (an inhibitor of adenyl cyclase) was stimulatory. The tumor promoter and LiCl, however, appear to stimulate hexose transport by different mechanisms.
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