Abstract
The induction of tyrosine transaminase by hydrocortisone, triamcinolone (Tr) and triamcinolone acetonide (TrA) in the rat was studied. The pretreatment of rats with phenobarbital was found to markedly reduce the magnitude of tyrosine transaminase induction by Tr and TrA. Similarly, o,p′DDD reduced the magnitude of enzyme induction by TrA; however, there was no such effect on hydrocortisone mediated enzyme induction. On the other hand, SKF 525A substantially increased enzyme induction by either Tr or TrA. When radioactive-labeled TrA was administered, phenobarbital decreased and SKF 525A increased the hepatic concentration of radioactivity. The possibility that the magnitude of induction of tyrosine transaminase by glucocorticoids is related to their rate of metabolism is discussed.
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