Alteration and clinical significance of cfDNA and CRP in children patients with hand-foot-and-muoth disease

Abstract

Objective To explore the clinical significance of changes of serum cfDNA and CRPin patients with hand-foot-and-muoth disease. Methods Serum levels of cfDNA, CPP were measured with fluorescent quantitation PCR and immunoturbidime, respectively in 108 cases of children patients with hand-foot-and-muoth and 108 healthy subjects children as control group. Results Serum cf DNA and CPP levels with hand-foot-andmuoth group(523.45±42.31)mg/L,(22.57±5.52)mg/L were significantly higher than those of control group detection results(260.18±20.56)mg/L,(2.88±0.82)mg/L(t=58.16,36.85,all P<0.05).And we observed the serum cf DNA and CPP levels in different severity extent of pneumonia,the results show that the serum increased gradually with the increase of the severity(t=29.80,13.68,all P<0.05).and the serum level of cfDNA was positive correlation with CRP(r=0.730,P<0.01). Conclusion The serum.cf DNA and CRP reflect situation of patients and extent of hand-foot-and-muoth disease, which have a close relationship between the clinical process of hand-foot-and-muoth disease and have significance value to evaluate the pathogenetic condition and prognosis. Key words: Hand foot and muoth disease; Deoxyribonucleic acid; C reactive protein