Alteraciones adquiridas de la coagulación

Abstract

Acquired coagulation disorders: Acquired coagulation disorders tend to be diagnosed in adulthood in patients without a history of coagulopathy. A large part of them are secondary to other underlying pathologies. The physiopathology of acquired coagulopathies differs greatly from one to another. Disseminated intravascular coagulation (DIC) is secondary to an activation of coagulation with secondary consumption of factors. Chronic liver disease leads to hypoproduction of coagulation factors and regulatory proteins of hemostasis. Acquired hemophilia A is secondary to production of a factor VIII inhibitor antibody. Lastly, both acquired von Willebrand disease and acquired factor XIII deficiency have several possible causes. Hemorrhagic symptoms vary from one to another, ranging from an absence of or very mild symptoms in certain cases of DIC or liver disease to life-threatening bleeding in acquired hemophilia A. Likewise, in the laboratory, each pathology has certain alterations by which a definitive diagnosis is confirmed. In general, treatment of the underlying causes is essential for controlling these coagulopathies and control of hemorrhagic symptoms is of vital importance.