Abstract
Abstract Inhalant drug abuse can result in sinonasal and pulmonary complications, including necrosis of the nasal cavity and upper aerodigestive tract. This case report focuses on a 26-year-old male who presented with nasal obstruction and was later diagnosed with endonasal necrosis associated with alprazolam (Xanax®) inhalation. Despite the known misuse of benzodiazepines, particularly through the oral route, inhalation remains a common method of misuse among adolescents. The patient’s symptoms improved after discontinuing alprazolam use and continuing nasal rinsing. The underlying mechanism of injury and the specific role of alprazolam inhalation in causing necrosis are not well understood, emphasizing the need for further research. Inhalant substance abuse is a significant issue among youth and young adults, necessitating targeted interventions and counseling to mitigate the potential gateway effect to more harmful substances.
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