Abstract
Induction of α-oxidation, a possible gluconeogenic process, which should produce odd-chain fatty acids from even-chain fatty acids, was studied in rats fasted or made diabetic with streptozotocin. When a ω-phenylated even-chain fatty acid, phenylbutyric acid (1.2 mmol/kg), was administered to rats under these conditions, a significant increase in the urinary excretion of benzoic acid, the metabolic end-product of ω-phenylated odd-chain fatty acids, was observed in fasted (3.54 ± 0.46 μmol/day) and diabetic (6.73 ± 2.10) rats (control, 0.58 ± 0.43; P < 0.001). Phenylated longer chain fatty acids, phenylhexanoic and phenyldecanoic acid, did not produce significantly more benzoic acid than did phenylbutryic acid. Although the rate of α-oxidation was very low compared to that of β-oxidation, these results suggested that α-oxidation of fatty acids was induced under fasting or diabetic conditions, and that α-oxidation might take place at the butyric acid stage.
Published Version
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