Abstract
The physiological and functional interaction between neuropeptide Y (NPY) and alpha-melanocyte stimulating hormone (α-MSH) with reference to anxiety and food intake is well documented. An attempt has been made to study the influence of melanocortin (MC) system on NPY induced antidepressant-like effect in rats using Porsolt's forced swim test as the behavioral paradigm. NPY (0.40–2.10 ng/rat), NPY Y1 and Y5 receptors agonist [Leu 31, Pro 34]-NPY (0.20–0.60 ng/rat) or selective MC4 receptors antagonist HS014 (0.01–0.07 ng/rat) dose dependently elicited antidepressant-like effect. On the other hand, α-MSH (100–400 ng/rat) resulted in high immobility suggestive of depression. Antidepressant-like effect of NPY (1.00–2.10 ng/rat) or [Leu 31, Pro 34]-NPY (0.40–0.60 ng/rat) was significantly reversed by prior treatment of α-MSH (100 ng/rat). While antidepressant action of NPY (0.40–1.00 ng/rat) or [Leu 31, Pro 34]-NPY (0.20–0.40 ng/rat) was enhanced by concurrent administration of HS014 (0.01 ng/rat), the locomotor activity in all the treatment groups was unaffected. These results suggest the possibility that MC and NPYergic systems may interact and regulate the depression via MC4 and NPY Y1 or Y5 receptors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
