Abstract
Background and Aims : Graft vasospasm due to inflammation and oxidative stress in human saphenous vein (HSV) grafts during or after coronary artery bypass grafting (CABG) operation is an important complication that limits long-term graft patency and functions. In our previous study, we showed that alpha lipoic acid (ALA) decreased ROS levels and MMP-2 expression/activity and α-smooth muscle actin expression in Tumor Necrosis Factor-α (TNF-α)-induced HSV grafts. The aim of the present study was to investigate the effect of ALA on vascular functional responses in TNF-α-induced HSV grafts.
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