Abstract
Purpose Cognitive adverse effects may accompany deep brain stimulation (DBS) treatment, as the basal ganglia have influence on widespread neocortical networks. The aim of this study was to investigate how complex motor-cognitive activities are processed in the subthalamic nucleus (STN) and internal globus pallidum (GPi). Methods Dystonia patients implanted with GPi-DBS electrodes ( n = 5), and individuals with Parkinson’s disease (PD) ( n = 4) or essential tremor ( n = 1) with STN-DBS electrodes performed two tasks involving the writing of single letters: 1. copying letters from a monitor; and 2. writing of any letter other than that appearing on the monitor. The cognitive load of the second task was increased relative to the first. Intracranial recordings of task-related oscillatory changes were assessed and compared. Results Local event-related alpha and beta desynchronization (ERD) were more expressed during the second task while the lower gamma synchronization (ERS) decreased regardless of the basal ganglia structure from which recordings were obtained or the clinical diagnosis. Task-related ERD differences recorded from the language-dominant left hemisphere correlated with a behavioural (RT) measure of cognitive effort. ERD changes declined after levodopa intake in PD patients. Conclusions The STN and Gpi participate in cognitive networks. Alpha and beta ERD seems to be essential during processing complex motor-cognitive tasks and increase with enhanced cognitive effort.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.