Alpha‐adrenoceptors: A critical review

Abstract

Medicinal Research ReviewsVolume 9, Issue 4 p. 407-533 Article Alpha-adrenoceptors: A critical review J. C. McGrath, J. C. McGrath Autonomic Physiology Unit, Institute of Physiology, University of Glasgow, Glasgow G12 8QQ John (Ian) C. McGrath: is Titular Professor in Physiology at Glasgow University, from which he received B.Sc. (1st class) Hons and Ph.D. degrees in Pharmacology. His main interests have been autonomic neuroeffector mechanisms originally at the fundamental level but eventually in applications to clinical problems and the development of new drugs. For work into subtypes of alpha-adrenoceptors and nonadrenergic, noncholinergic mechanisms he received the Sandoz Prize of the British Pharmacological Society (1980) and the 1st Pfizer Award in Biology (1983). Recently his main interests have been how physiological factors modulate neurotransmitter receptors and the molecular mechanisms involved in their activation and coupling mechanisms.Search for more papers by this authorC. M. Brown, C. M. Brown Department of Pharmacology, Syntex Research Centre, Riccarton, Edinburgh EH14 4AS, Scotland Christine M. Brown: is presently Head of the ligand-binding laboratory at Syntex Research Centre, Edinburgh. She obtained her B.Sc. Hons (Anatomy and Experimental Pathology) from St. Andrews University and her Ph.D. (Pharmacology) from Glasgow University. Her current interests include the characteristics of 5-HT receptors and alpha-adrenoceptors in the central nervous system and changes associated with pathological conditions.Search for more papers by this authorV. G. Wilson, V. G. Wilson Autonomic Physiology Unit, Institute of Physiology, University of Glasgow, Glasgow G12 8QQ V. G. Wilson: is presently a research fellow in the Institute of Physiology, Glasgow University. He obtained both his B.Sc. Hons (Pharmacy) and Ph.D. (Pharmacology) from the University of Aston, Birmingham (UK). In 1984 he was a recipient of Royal Society European Science Exchange Fellowship to work with Professor U. Trendelenburg at the Institüt für Pharmakologie und Toxikologie der Universität Würzburg, FRG. He joined Ian McGrath's group in 1986. His main research interests are the postjunctional consequence and mechanisms of interaction between different receptor systems, particularly with subtypes of adrenoceptors. Other interests include Aston Villa F.C. and the music of Miles Davis and John Coltrane.Search for more papers by this author J. C. McGrath, J. C. McGrath Autonomic Physiology Unit, Institute of Physiology, University of Glasgow, Glasgow G12 8QQ John (Ian) C. McGrath: is Titular Professor in Physiology at Glasgow University, from which he received B.Sc. (1st class) Hons and Ph.D. degrees in Pharmacology. His main interests have been autonomic neuroeffector mechanisms originally at the fundamental level but eventually in applications to clinical problems and the development of new drugs. For work into subtypes of alpha-adrenoceptors and nonadrenergic, noncholinergic mechanisms he received the Sandoz Prize of the British Pharmacological Society (1980) and the 1st Pfizer Award in Biology (1983). Recently his main interests have been how physiological factors modulate neurotransmitter receptors and the molecular mechanisms involved in their activation and coupling mechanisms.Search for more papers by this authorC. M. Brown, C. M. Brown Department of Pharmacology, Syntex Research Centre, Riccarton, Edinburgh EH14 4AS, Scotland Christine M. Brown: is presently Head of the ligand-binding laboratory at Syntex Research Centre, Edinburgh. She obtained her B.Sc. Hons (Anatomy and Experimental Pathology) from St. Andrews University and her Ph.D. (Pharmacology) from Glasgow University. Her current interests include the characteristics of 5-HT receptors and alpha-adrenoceptors in the central nervous system and changes associated with pathological conditions.Search for more papers by this authorV. G. Wilson, V. G. Wilson Autonomic Physiology Unit, Institute of Physiology, University of Glasgow, Glasgow G12 8QQ V. G. Wilson: is presently a research fellow in the Institute of Physiology, Glasgow University. He obtained both his B.Sc. Hons (Pharmacy) and Ph.D. (Pharmacology) from the University of Aston, Birmingham (UK). In 1984 he was a recipient of Royal Society European Science Exchange Fellowship to work with Professor U. Trendelenburg at the Institüt für Pharmakologie und Toxikologie der Universität Würzburg, FRG. He joined Ian McGrath's group in 1986. His main research interests are the postjunctional consequence and mechanisms of interaction between different receptor systems, particularly with subtypes of adrenoceptors. Other interests include Aston Villa F.C. and the music of Miles Davis and John Coltrane.Search for more papers by this author First published: October/December 1989 https://doi.org/10.1002/med.2610090403Citations: 84 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume9, Issue4October/December 1989Pages 407-533 RelatedInformation