Abstract
tend to aggregate at the periphery of the tumor masses, resulting in an inflammatory “cuff.” Each tumor has a variable content of collagenized, fibroblastic stroma that serves to compartmentalize individual aggregates of tumor cells in some areas. Our case showed these histologic features with significant pilosebaceous differentiation and a prominent vascular component (Fig. 1). All cases of LELCS have shown positive staining for cytokeratins, favoring an epidermal, follicular, or sudoriferous origin. More than half were positive for EMA, favoring a sudoriferous origin for this neoplasm. However, squamous cell carcinomas and sebaceous carcinomas can show also EMA-positive 2. Carbone A, Micheau C. Pitfalls in microscopic diagnosis of undifferentiated carcinoma of the nasopharyngeal type (lymphoepithelioma). Cancer 1982$0:1344-50. 3. Klijanienko J, Micheau C, Azli N, et al. Undifferentiated carcinoma of the nasopharyngeal type of the tonsil. Arch Otolaryngol Head Neck Surg 1989;115:731-3. 4. Bosch JD, Kudryk WH, Johnson GH. The malignant lymphoepithelial lesion of the salivary glands. J Otolaryngol 1988;17:187-90. 5. Butler AE, Colby TV, Weiss L, et al. Lymphoepithe lioma-like carcinoma of the lung. Am J Surg Path01 1989; 13632-5. 6. Begin LR, Eskandari J, Joncas J, et al. Epstein-Barr virus related lymphoepithelioma-like carcinoma of the lung. J Surg Oncol 1987;36:280-5. 7. Wick MR, Scheithauer BW, Weiland LH, et al. Primary thymic carcinomas. Am J Surg Path01 198%6:61320.
Published Version
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