Allogeneic hematopoietic stem cell transplant for hematological malignancies from mismatched 9/10 human leukocyte antigen unrelated donors: comparison with transplants from 10/10 unrelated donors and human leukocyte antigen identical siblings

Abstract

We studied the outcome of 213 patients who received allo-HSCT for hematological malignancies, 121 (57%) from HLA identical siblings, 63 (29%) from 10/10 HLA identical unrelated donors and 29 (14%) from 9/10 HLA mismatched unrelated donors. Engraftment was lower in the 9/10 HLA group (90%) than in the 10/10 HLA group (95%) than in the sibling group (99%); 3 months CI of aGVHD ≥ 2 was 32% (23–41), 20% (15–26) and 27% (23–32) respectively; the one year CI of extensive cGVHD was 21% (13–30), 9% (5–13) and 17% (14–21) respectively. The median OS was 10 months (5–21), 18 months (11-NR) and 60 months (31-NR) respectively with 2-years probability of 19% (8–44), 43% (31–59) and 63% (54–74) respectively. TRM was significantly higher in the 9/10 HLA group with 1 year CI of 45% (35–55), compared to 33% (27–39) in the unrelated 10/10 HLA group and 12% (9–15) in the identical siblings group (p < 0.001).