Abstract
The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of Coffea arabica L. oil and Olea europaea L. oil on MAL-intoxicated male rats. Six equal groups of animals were used for conducting this study (n = 10). Animals in group one were designated as control, animals belonging to group two were exposed to MAL in the measure of hundred mg per kg BW (body weight) for forty-nine days (seven weeks), rats in the third and fourth groups were administered with 400 mg/kg BW of Coffea arabica L. and Olea europaea L. oils, respectively, and the same amount of MAL as given to the second group. Groups five and six were administered with the same amount of Coffea arabica L. oil and Olea europaea L. oil as given to group three. Exposure of rats to 100 mg/kg body weight of MAL resulted in statistical alteration of the serum lipid profile. A marked decline was noticed in the severe changes of these blood parameters when MAL-intoxicated rats were treated with Coffea arabica L. oil and Olea europaea L. oil. Two compounds from Coffea arabica L. oil (Chlorogenic acid) and Olea europaea L. oil (Oleuropein) demonstrated good interaction with xanthine oxidase (XO) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) enzymes that are associated with cholesterol production. The present study indicated that Coffea arabica L. oil and Olea europaea L. oil could be considered prospective and potential healing agents against metabolic conditions induced by MAL.
Highlights
In the present time, the chemicals that are considerably used all over the world are pesticides
This study aims to evaluate the biochemical perturbations stimulated by malathion (MAL) in the serum lipids profile of rats and the protective influences of Coffea arabica L. oil and Olea europaea L. oil against the oxidative damage and stress caused by MAL intoxication
The results of this study demonstrated that the levels of TG considerably (p ≤ 0.001) surged in the MAL-intoxicated G2 group of rats, as measured against the G1 rats
Summary
The chemicals that are considerably used all over the world are pesticides. It is one of the most toxic materials for humans. As the nature of pesticides is poisonous, it acts as a potential hazard for animals, human beings, various other organisms, and the environment. Even though pesticides are manufactured to kill only the intended insect, it has an adverse effect on the environment and human if not used correctly. The respiratory complex of the mitochondria gets inactivated because of the oxidative stress induced by malathion [7,8,9]. Many previous studies mentioned that the exposure of malathion results in accelerated oxidative degradation of lipids in the RBCs (erythrocytes) of rats and their brain and liver [6,10,11]
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