Allergic Cutaneous and Visceral Angioedema Secondary to Clozapine: A Case Report

Abstract

This report stresses on the occurrence of a rare adverse reaction to clozapine, i.e. allergic cutaneous and visceral angioedema, in a patient with treatment resistant schizophrenia (TRS). We report the case of a schizophrenic patient who was resistant to treatment and developed an allergic reaction involving her skin and gastro-intestinal system upon the commencement of clozapine. She was then treated with a combination pharmacotherapy which left some residual symptoms. The manifestation of allergic reactions to clozapine and its management strategies are discussed in the paper. There is a pressing need to develop a new psychotropic which is on par with clozapine Laporan ini menerangkan kejadian tindak balas ubat clozapine yang jarang berlaku, iaitu alahan kutaneus dan angioedema visera, pada seorang pesakit skizofrenia yang tidak menunjukkan kesan terhadap rawatan ubat-ubatan yang biasa. Kami melaporkan seorang pesakit skizofrenia rintang-rawatan yang mengalami masalah alahan pada kulit dan sistem gastro-usus sejurus beliau menerima rawatan ubat clozapine. Beliau kemudiannya dirawat dengan kombinasi beberapa ubat-ubatan, namun masih mengalami gejala-gejala residual. Manifestasi alahan kepada ubat clozapine and strategi perawatan dibincangkan di dalam laporan kes ini. Terdapat keperluan yang mendesak bagi penghasilan ubat psikotropik yang setanding clozapine untuk merawat pesakit, memandangkan masalah alahan ubat seperti laporan kes ini