Abstract
AllerGen’s 8th research conference
Highlights
Asthma is the most prevalent chronic disease among children and affects 235 million people worldwide [1]
To study possible mechanisms involved in the response, inflammation severity was analyzed in ILC2, mast cell, eosinophil-deficient, Cd34−/− and Tlr4−/− mice exposed to Methanosphaera stadtmanae (MSS) using broncho-alveolar lavages cell counts
We aimed to assess the percentage of drug-induced anaphylaxis cases among all Emergency Department (ED) visits due to anaphylaxis in a pediatric and an adult ED in Montréal and to determine factors associated with severe reactions
Summary
Asthma is the most prevalent chronic disease among children and affects 235 million people worldwide [1]. Conclusions: Maternal smoking was associated with differences in umbilical cord blood dendritic cell mitochondrial DNA methylation in 2 out of the 3 regions examined These effects on mtDNA may be related to the known effects of smoking on oxidative stress balance, and may affect dendritic cell function and the development of allergic disease. Conclusions: Our results confirm that maternal diet and supplement use are key determinants of DHA content in breastmilk, and further identify several non-dietary factors that may influence the intake of this important bioactive nutrient among breastfed infants in Canada. These findings may be relevant to nutrition-based allergic disease prevention strategies. The impact of these compositional changes on the development of gut immunity and atopic disease later in life requires further study
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