Abstract
Growth performance as well as marbling is the main breeding objectives in Japanese Black cattle, the major beef breed in Japan. A previous study has identified the c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG (non-SMC condensin I complex, subunit G) gene that leads to the amino acid change p.Ile442Met in the NCAPG protein, which is a candidate causative variation for a bovine carcass weight (CWT) quantitative trait locus (QTL). In this study, we first confirmed the association of the c.1326T>G SNP with the growth-related traits, CWT, rib eye area (REA) and rib thickness (RT), and showed significant effect of the SNP genotypes on the marbling trait, beef marbling score (BMS), in the Japanese Black beef cattle population of the Niigata prefecture, with the G allele being associated with a favorable phenotype of these traits. Thus, we concluded that the c.1326T>G SNP is useful for effective marker-assisted selection to increase meat quality and meat productivity in Japanese Black beef cattle of the Niigata prefecture. Furthermore the frequency of the favorable G allele of the c.1326T>G SNP in the Niigata prefecture population was significantly lower than the frequency of this allele in Japanese Black cattle population of the Kagoshima prefecture. However, no statistically significant difference was detected between the allele frequencies estimated by maternal alleles in the half-sib progeny steers in the Niigata prefecture population and obtained in Japanese Black cattle population of the Kagoshima prefecture.
Highlights
Growth performance has an important effect on the economics of beef production [1]
Significant differences in the growth-related traits, carcass weight (CWT), rib eye area (REA) and rib thickness (RT) were detected among the genotypes of the c.1326T>G single nucleotide polymorphism (SNP) in the Niigata prefecture population, with the G allele being associated with a favorable phenotype of these traits by analysis using the model that included the SNP genotype as the fixed effect and the sire as the random effect (Table 1)
These results of CWT and REA were consistent with data obtained in previous study in the Kagoshima prefecture population [7], and confirmed that the NCAPGc. 1326T>G SNP is a causative variation for bovine CWT [2]
Summary
Growth performance has an important effect on the economics of beef production [1]. it is greatly interesting to obtain better knowledge on the molecular architecture of growth characteristics and to generate new opportunities for more effective marker-assisted selection.A previous study showed that the c.1326T>G single nucleotide polymorphism (SNP) in the NCAPG (nonSMC condensin I complex, subunit G) gene, which leads to the amino acid change of Ile442 to Met442 in the encoded protein, was identified as a candidate causative variation for a bovine carcass weight (CWT) quantitative trait locus (QTL) on bovine chromosome 6 [2]. Hoshiba et al [7] showed that the c.1326T>G SNP was associated with CWT and rib eye area (REA), subcutaneous fat thickness (SFT) and carcass yield estimate (YE) in Japanese Black beef cattle population in the Kagoshima prefecture, with the G allele of the SNP being associated with a high level of the CWT, REA and YE, and a low level of the SFT. It was necessary to investigate whether the association of the c.1326T>G SNP with growth-related traits could be replicated in Japanese Black beef cattle population of the Niigata prefecture and to analyze the effects of the SNP genotypes on the meat quality trait, beef marbling score (BMS), in order to confirm the application of the c.1326T>G SNP to effective marker-assisted selection in the Niigata population of Japanese Black cattle. We investigated allele frequency distribution of the SNP in the Niigata population
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