Allantoin and urate as the supressors of genotoxic effect of the ultraviolet irradiation with wavelength 300-400 nm

Abstract

Genotoxicity of ultraviolet radiation with wavelength 300-400 nm (sunlight uVR) is mediated by the generation of reactive oxygen species. The research which was carried out on the base of developed early bacterial model indicated the existence of uV-protecting activity of allantoin, formed from uric acid in organisms of all vertebrates except human and anthropoid apes. The uric acid which is the end-product of purine catabolism in the organism of anthropoid apes, does not possess statistically significant protective effect. Safety of allanoin makes it a perspective component of sunlight protectors.