Abstract
Background The effects of ischemia are first realized in the subendocardium and progress transmurally. Hence, detection of the transmural extent of myocardial perfusion (MP) defects has important diagnostic/prognostic implications. Systolic MP imaging using ECG-gated methods has been shown to provide improved visualization of subendocardial defects [1]. We developed an innovative non-ECGgated perfusion CMR technique capable of imaging all slices at the same systolic phase, and hypothesized that it improves visualization of the transmural extent of MP defects compared to the conventional method in CMR studies of CAD patients.
Highlights
The effects of ischemia are first realized in the subendocardium and progress transmurally
Among all patients who had an abnormal CMR study (n=8), the detected stress myocardial perfusion (MP) defects matched between the two methods
All of the perfusion defects for the proposed method were imaged at the end-systolic phase, enabling reliable determination of their transmural extent (Fig. 1)
Summary
The effects of ischemia are first realized in the subendocardium and progress transmurally. Detection of the transmural extent of myocardial perfusion (MP) defects has important diagnostic/prognostic implications. Systolic MP imaging using ECG-gated methods has been shown to provide improved visualization of subendocardial defects [1]. We developed an innovative non-ECGgated perfusion CMR technique capable of imaging all slices at the same systolic phase, and hypothesized that it improves visualization of the transmural extent of MP defects compared to the conventional method in CMR studies of CAD patients
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