ALL-310: The Prognostic Impact of Lipid Profiles in Adult Egyptian Acute Leukemia Patients

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Context Acute leukemia is a malignant disorder that results from clonal proliferation of lymphoid and myeloid blast cells. Several studies have reported some changes in lipid metabolism at time of diagnosis of leukemia. Although investigators have reported decreased total cholesterol, decreased high density lipid (HDL), and elevated triglycerides (TG) in leukemic patients; there is a controversy about these changes among different types of leukemia and between children and adult patients, in addition to different data about their impact on prognosis. Objective Lipid profiles were examined at the time of diagnosis of acute leukemia in order to correlate them with response to therapy. Design A prospective study included 50 newly diagnosed patients with acute leukemia between 2018 and 2019. Setting The study was carried out at Oncology Center Mansoura University (OCMU). Patients Thirty-four patients were diagnosed with AML (68%), while 16 patients diagnosed with ALL (32%). Twenty-five patients were male (50%), and 25 were female (50%). Interventions Lipid profile and body mass index (BMI) were obtained. Main outcome measures Complete response rate and overall survival. Results Overweight/obese patients showed statistically significant association with female patients than male patients (p=0.009). By comparing the lipid profile between overweight/obese patients and other patients, there was no statistically significant association. In addition, 76.7% of AML patients were overweight orobese (p 0.015), and 81.3% of ALL patients showed hypertriglyceridemia (p=0.014). There was no statistically significant association between lipid profile and complete response (CR) rate; however, there was a marginally significant association between non-CR rate and overweight and obese patients (p=0.051). In addition, there was no impaction of BMI or lipid profile in overall survival among acute leukemia patients. Conclusions Female acute myeloid leukemia patients were more commonly associated with overweight and obesity, and high TG level was found to be associated with acute lymphoid leukemia. Changes in lipid profile showed no impact on complete response rate and overall survival in acute leukemia patients.