Abstract
AbstractA series of gold (I) phoshpine complexes with diverse alkynyl ligands [Au(C≡CR)(PTA)] (R=C6H11OH, 1; C5H9OH, 2; C15H11OH, 3; C19H27O2, 4; C18H23O2, 5; C9H12N, 6; CH2OCH2C6H5, 7; C6H4OCH3, 8; PTA=1,3,5‐Triaza‐7‐phosphaadamantane) have been synthesized and characterized using a range of spectroscopic techniques. Complex 1 and 3 show an infinite one–dimensional S–type and zigzag aurophilic chain, respectively, whereas complex 2 containing 1‐ethynyl‐1‐cyclohexanol gives an approximate linear two–dimensional aurophilic chain, through intra/intermolecular Au(I)⋯Au(I) interactions as well as hydrogen bonding interactions between hydroxy groups of alkynyl ligands and PTA. Solid complexes 1–8 display strongly room/low–temperature emissive of 477–613 nm with the emission lifetime of 0.40–14.0 μs. All the complexes display higher cytotoxicities against MCF‐7, with the cytotoxicity decreasing in the following order 4>8>5>3>7>6>2>1. Complex 4 and 5 stand out for the highest selectivity towards MCF–7 (IC50=0.63–0.78 μM) compared with normal human embryonic lung fibroblasts (helf) (IC50=14.85–18.13 μM), which makes those complexes attractive for breast cancer therapy.
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