Abstract
An overview is presented of the well-established role of alkaloids in drug discovery, the application of more sustainable chemicals, and biological approaches, and the implementation of information systems to address the current challenges faced in meeting global disease needs. The necessity for a new international paradigm for natural product discovery and development for the treatment of multidrug resistant organisms, and rare and neglected tropical diseases in the era of the Fourth Industrial Revolution and the Quintuple Helix is discussed.
Highlights
A set of 2194 plant-derived metabolites, including 290 diverse alkaloids, were evaluated in silico against three dengue virus proteins, the results indicated that polyphenolics, not alkaloids, were the strongest binding compounds [167]
There is much still to be learned about alkaloids and their beneficial role in health care
The era of 4IR and the Quintuple Helix bring together the power of large data systems, artificial intelligence, machine learning, laboratory AI systems, and knowledge exchange based on collaborative integrated and environmentally sensitive programs which can evolve for the generation of new, biologically significant molecular entities through the sustainable assessment of known alkaloids
Summary
Alkaloids are a paradox and an enigma. Inexplicable, contradictory, mysterious, and yet essential for all forms of life. The focus will be on the role of alkaloids in the complex milieu of the evolving discovery process, for overcoming multiple drug resistance (MDR), and for the treatment of rare and tropical diseases, including the neglected tropical diseases (NTDs). It will approach the question of how the present and future levels of technological development in the 4IR can enhance the utilization of alkaloids as drugs in new ways to address these global health needs and the welfare of the patient. What are the paradigms in the strategies of the discovery programs that need to change for alkaloids as drugs to be sustainable [21]?
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