Abstract
The Bocconieae tribe, consisting of only the genera Macleaya and Bocconia, possesses significant economic and medicinal value and plays an important role in health management for people in developing countries. During the past decades, research on metabolites and relative pharmacology, including the isolation and identification of a variety of molecules, has shed light on the tribe. Among those molecules, isoquinoline alkaloids, and their antimicrobial, antifungal, and anti-inflammatory activities are especially noteworthy. This paper presents a comprehensive compilation of current research progress, with emphasis on the alkaloids and their distribution, phytochemical and pharmacological investigation, toxicity and side effects, related chemotaxonomy and future use prospects, and hopefully provides a valuable reference as an effort to promote further exploration and application of this tribe.
Highlights
The Papaveraceous plants are very well-known for their extensive economic use as well as medicinal ones, which are directly associated with their rich production of alkaloids with novel structures and significant bioactivities
M. cordata were investigated in vitro against the fish parasite Ichthyophthirius multifiliis by a bioactivity-guided isolation method, and caresults showed that chloroform extract exhibited promising activity with 100% antiparasitic efficacy at the concentration of 70.0 mg/L after 4 h of exposure [52]
M. cordata could lessen the level of serum lactate dehydrogenase (LDH) and mortality rate of rats, while increasing the ratio of serum albumin/globulin (A/G), protecting cellular membrane effectively and inhibiting fibrosis in rats with chromic hepatic injury caused by tetrachloromethane
Summary
The Papaveraceous plants are very well-known for their extensive economic use as well as medicinal ones, which are directly associated with their rich production of alkaloids with novel structures and significant bioactivities. Nine species, distributed mainly in tropical areas of Mexico, Central and Southern America [2]. B. arborea is employed for the treatment of diverse infectious diseases and is variously known in Mexico as llora sangre (weeping blood), cocoxíhuitl, ahuacachilli, mano de león (lion’s hand), palo del diablo (devil’s stick), palo amarillo (yellow stick). This paper compiles complete data of alkaloids from the plants of the tribe. Bocconieae, focusing on their distribution, isolation, structural features, and pharmacological activities, and hopefully may provide a useful reference for further studies on this tribe
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