Abstract
Alkaline phosphatase was studied in the proximal tubules of kidneys from rats treated with various nephrotoxins. Changes in activity and location of alkaline phosphatase were demonstrated both with dose levels which produced serious morphological lesions and with dose levels which caused no morphological changes. By varying the duration of treatment it was shown that changes in alkaline phosphatase activity occurred before morphological changes appeared. Electron microscopic studies showed a close relationship between changes in alkaline phosphatase activity and damage of the brush border. It is concluded that alkaline phosphatase histochemistry could possibly be used as an early and sensitive index of nephrotoxicity.
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