Abstract
Rats were presented with a choice between water and 2.0% (0.34M) NaC1 solution and their fluid intake was measured for 7 days. Then the rats were injected with Aldactazide-A on odd days and with 0.88% (0.15M) NaC1 solution on even days. This procedure was repeated for 12 days at which time the animals had received six tests under each of the injections. The results indicated that the rats consumed more hypertonic saline solution when injected with Aldactazide than they did with isotonic NaC1 injections. The water intake of these animals was not affected by the different injections. With repeated Aldactazide injections the animals showed an increase of saline consumption over the six sessions. These results suggest that Aldactazide is an effective agent for inducing sodium appetite in rats.
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