Abstract
We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) cancer. PubMed and Embase were searched up to July 2012 and the reference lists of studies included in the analysis were examined. Random-effects models were used to estimate summary relative risks (RR) and 95% confidence interval (CI). Nineteen studies, 8 cohort and 11 case-control studies, were included. In highest versus lowest meta-analyses, alcohol drinking was associated with significantly increased risk of UADT second primary cancers (RR, 2.97; 95% CI, 1.96-4.50). Significantly increased risks were also observed for UADT and lung combined (RR, 1.90; 95% CI, 1.16-3.11) and all sites (RR, 1.60; 95% CI, 1.22-2.10) second primary cancers. For an increase in the alcohol intake of 10 grams per day, dose-response meta-analysis resulted in a significantly increased RR of 1.09 (95% CI, 1.04-1.14) for UADT second primary cancers. Alcohol drinking in patients with UADT cancer is associated with an increased risk of second primary cancers. Studies conducted in alcohol drinking patients with UADT cancer and evaluating the effect of alcohol cessation on second primary cancer and other outcomes are needed. Our results emphasize the importance of prevention policies aiming to reduce alcohol drinking. Health-care professionals should encourage alcohol drinking patients with UADT cancer to reduce their consumption and reinforce the surveillance of this at-risk subpopulation.
Highlights
Cancers of the upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) represent a major public health issue worldwide, and are the fourth most frequently occurring cancers in men and women with 1,116,405 new cases and the second leading cancer mortality cause with 763,238 deaths estimated from population-based cancer registries in 2008
One medical concern for UADT cancer survivors is the risk of developing new primary cancers, in particular for patients diagnosed with oral cavity, pharynx, and larynx cancers, for whom the 5-year relative survival rates are of approximately 60% to 65% [2]
Studies were included if they met the following inclusion criteria: original research article, cohort or case–control study design conducted in adults with UADT cancer as first primary cancer site, assessment of alcohol consumption, with second primary cancer as outcome and report of the hazard ratio (HR), relative risk (RR) or odds ratio (OR), and 95% confidence interval (CI) for alcohol intake
Summary
Cancers of the upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) represent a major public health issue worldwide, and are the fourth most frequently occurring cancers in men and women with 1,116,405 new cases and the second leading cancer mortality cause with 763,238 deaths estimated from population-based cancer registries in 2008. Their incidence has reached age-standardized rates of 14.5 and 13.7 per 100,000 in 2008 in Europe and the United States, respec-. We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
