Abstract
BackgroundParkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.ObjectiveTo assess the associations between alcohol consumption and PD risk.MethodsWithin NeuroEPIC4PD, a prospective European population‐based cohort, 694 incident PD cases were ascertained from 209,998 PD‐free participants. Average alcohol consumption at different time points was self‐reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.ResultsNo associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5–29.9 g/day) were at ~50% higher risk compared with light consumption (0.1–4.9 g/day), but no linear exposure–response trend was observed. Analyses by beverage type also revealed no associations with PD.ConclusionOur data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Highlights
The etiology of Parkinson’s disease (PD) is complex and likely involves both genetic and environmental factors.[1]
We present risk estimates for average alcohol consumption 12 months prior to the recruitment and during lifetime, that is, since the age of 20 years, as well as the PD risks associated with different types of alcoholic beverages
We observed no associations between baseline or lifetime alcohol consumption and the risk of PD in the NeuroEPIC4PD cohort
Summary
The etiology of Parkinson’s disease (PD) is complex and likely involves both genetic and environmental factors.[1].
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