Abstract
Introduction: Excessive alcohol consumption injures the immune system, predisposing the host to the development of severe infections. Indeed, alcoholic patients with systemic bacterial infection frequently present with granulocytopenia which is an indicator for increased mortality. How alcohol impairs the granulopoietic response remains unclear. Methods: To determine whether alcohol affects the increase in primitive hematopoietic precursor cell commitment to granulocyte lineage development in response to bacteremia, acute alcohol intoxication was induced in male Balb/c mice maintained on a Lieber-DeCarli low fat liquid alcohol diet for 5 weeks by intraperitoneal injection (i.p.) of alcohol (20% alcohol in saline at a dose of 5 g alcohol/kg).
Published Version
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