Abstract
One of the plants found in East Kalimantan is the Drancotomelon dao (sengkuang) plant. Previous tests demonstrated the presence of anti-inflammatory activity of D. Dao leaf extract through the reduction of proinflammatory mediators such as TNF-?, IL-1?, and IL-6 which were induced by bacteria. This study aims to determine the anti-inflammatory activity of the methanol extract of the stem bark of the Sengkuang plant in a rat model of rheumatoid arthritis induced by complete freund's adjuvant (CFA) to determine the anti-inflammatory potential of other parts of the sengkuang plant. In this test, rat models of rheumatoid arthritis induced using CFA were divided into 4 treatment groups: negative group (NaCMC), positive group (methyl prednisolone), test group 1 (sengkuang extract 50 mg/KgBW/day), test group 2 (lengkuang extract). 200 mg/KgBB/day). Observation of its anti-inflammatory effect was observed for 14 days. Analysis of the data in this study used a one-way ANOVA with joint thickness dependent variable and zinc dose independent variable. Sengkuang extract at doses of 50 and 200 mg/KgBW/day can reduce joint thickness in animals induced with CFA. The activity of reducing joint thickness showed significance in zinc extract at a dose of 50 mg/KgBW/day on the 14th day. Methanol extract of sengkuang has anti-inflammatory activity in CFA-induced rheumatoid arthritis rats at an optimal dose of 200 mg/KgBW/day, has an anti-inflammatory effect that is good enough to reduce edema volume in arthritis rats.
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