Akraba Dışı Kordon Kanı Kaynaklı Kök Hücre Transplantasyonu Retrospektif Analizi

Abstract

Objective: Cord blood stem cells are used for hematopoietic stem cell transplantation (HSCT) in the treatment of hematological malignant and non-malignant diseases, especially in pediatric patients. In this present study, we aimed to evaluate the retrospective analysis of HLA match and survival between donor and patients who underwent cord blood transplantation through the Istanbul University Faculty of Medicine Bone Marrow Bank. Materials and Methods: In order to research the related factors of umbilical cord blood transplantation in Turkey, 102 cases of umbilical cord blood transplantation performed between 2008 and 2014 were analyzed retrospectively. Cord blood unit search applications were performed through Istanbul University, Istanbul Medical Faculty, Bone Marrow Bank. Results: It was, on average, 45 days between the search request and transplantation (range: 11-113 days). Average age of the patients was 42.48±2.8 (1-192 months), male-to-female ratio was 64/38. The most frequent diseases resulting in transplantation were SCID (n=23), AML (n=13), osteopetrosis (n=10), ALL (n=10) and other diseases. There were 38 (37%) cord blood transplantations with matched HLA-A,-B,-DR; 54 (52%) mismatched for HLA-A or -B antigens; 9 (9%) mismatched for HLA-DR only and 1 (1%) mismatched for HLA-B and -DR antigens. The overall survival rate after HSCT with cord blood was 81.5% (n=31/39). The overall survival rate of the patients with HLA class-I antigens mismatch is 48.1% (26/54), the patients with HLA classII antigens mismatch was 22.2% (2/9) after the HSCT. Conclusion: In conclusion, we found a significant effect in patients undergoing cord blood transplantation with 6/6 HLA matching on overall survival.