A-Kinase anchoring protein-13 (AKAP13) may be required for protein kinase A (PKA)-mediated aromatase Expression in granulosa cells

Abstract

Cyclic AMP (cAMP) is the main intracellular messenger mediating follicle stimulating hormone (FSH) stimulation of aromatase expression in granulosa cells (GCs). An intact PKA pathway in GCs is critical for peak gonadotropin signaling. We have previously shown that AKAP13 is necessary for optimal gonadotropin signaling through cAMP response element binding protein and that both FSH-dependent induction of aromatase and basal aromatase message is decreased with knockdown of AKAP13 in ovaries of AKAP13 conditional knockout mice and in a granulosa cell tumor cell line.