Abstract
BackgroundAK098656 may be an adverse factor for coronary heart disease (CHD), especially in patients with hypertension. This study aimed to analyze the effect of AK098656 on CHD and CHD with various complications.MethodsA total of 117 CHD patients and 27 healthy control subjects were enrolled in the study. Plasma AK098656 expression was determined using the quantitative real-time polymerase chain reaction. Student’s t-test was used to compare AK098656 expression levels in different groups. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to quantify the discrimination ability between CHD patients and health controls and between CHD and CHD + complications patients. The relationship between AK098656 and coronary stenosis was analyzed using Spearman’s correlation.ResultsAK098656 expression was remarkably higher in CHD patients than in healthy controls (P = 0.03). The ROC curve revealed an effective predictive AK098656 expression value for CHD risk, with an AUC of 0.656 (95% CI 0.501–0.809). Moreover, AK098656 expression was increased in CHD + complications patients compared to CHD patients alone (P = 0.005), especially in patients with hypertension (CHD + hHTN, P = 0.030). The ROC curve revealed a predictive AK098656 prognostic value for discriminating between CHD and CHD + hHTN patients, with an AUC of 0.666 (95% CI 0.528–0.805). There was no significant difference in AK098656 expression in CHD patients with diabetes mellitus compared to CHD patients alone. In addition, AK098656 expression in CHD patients was positively correlated with stenosis severity (R = 0.261, P = 0.006).ConclusionAK098656 expression was significantly increased in patients with CHD, especially those with hypertension, and its expression level was positively correlated with the degree of coronary stenosis. This implied that AK098656 may be a risk factor for CHD and can potentially be applied in clinical diagnosis or provide a novel target for treatment.
Highlights
Cardiovascular disease is the leading cause of death worldwide
AK098656 expression correlation for coronary heart disease (CHD) risk AK098656 expression level was significantly higher in CHD patients compared to healthy controls (P = 0.038; Fig. 1A)
In order to quantify the discrimination ability between healthy controls and CHD patients, Receiver operating characteristic (ROC) curve analysis revealed that AK098656 was a valuable predictor for CHD risk (AUC = 0.656, 95% CI 0.501– 0.809; Fig. 1B)
Summary
Cardiovascular disease is the leading cause of death worldwide. Coronary heart disease (CHD) is the most harmful disease and leading cause of hospitalization and death among adult heart disease patients [1,2,3]. Multiple studies have shown that controlling the risk factors can significantly reduce CHD morbidity and mortality [4,5,6,7,8]. Current research has shown that some nontraditional factors, such as autoimmune diseases, high sensitivity C-reactive protein, and homocysteine, play important roles in the occurrence and development of CHD and need to be given sufficient attention. AK098656 may be an adverse factor for coronary heart disease (CHD), especially in patients with hyper‐ tension. This study aimed to analyze the effect of AK098656 on CHD and CHD with various complications
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